logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0102 : MARP2, Ankrd2

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesankyrin repeat domain-containing protein 2 isoform a [Homo sapiens]; ankyrin repeat domain-containing protein 2 isoform a; ankyrin repeat domain-containing protein 2; skeletal muscle ankyrin repeat protein; Ankyrin repeat domain-containing protein 2; Skeletal muscle ankyrin repeat protein; hArpp
Gene NamesANKRD2; ARPP; ankyrin repeat domain 2 (stretch responsive muscle)
Gene Locus10q23; chromosome 10
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_065082 NM_020349 26287 Q9GZV1 610734 HGNC:495 12460 hsa:26287

* Information From OMIM

Description: ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response to physiologic stress, injury, and hypertrophy (Miller et al., 2003).

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* Structure Information

1. Primary Information

Length: 360 aa

Average Mass: 39.859 kDa

Monoisotopic Mass: 39.835 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 103 ---
Shigella flexneri OspC protein 1. 152208229.00.0
Shigella flexneri OspC protein 2. 258306236.00.0

3. Sequence Information

Fasta Sequence: SB0102.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 18310072] Hayashi C, Ono Y, Doi N, Kitamura F, Tagami M, Mineki R, Arai T, Taguchi H, Yanagida M, Hirner S, Labeit D, Labeit S, Sorimachi H, Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem. 2008 May 23;283(21):14801-14. doi: 10.1074/jbc.M708262200. Epub 2008

Cleavage sites (±10aa)


Arg103 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23811403] Wu Y, Ruggiero CL, Bauman WA, Cardozo C, Ankrd1 is a transcriptional repressor for the androgen receptor that is downregulated by testosterone. Biochem Biophys Res Commun. 2013 Aug 2;437(3):355-60. doi:

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