logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0103 : [beta]2-Adaptin, AP2B1

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesAP-2 complex subunit beta [Rattus norvegicus]; AP-2 complex subunit beta; AP105B; beta-adaptin; beta2-adaptin; adaptor protein complex AP-2 subunit beta; adapter-related protein complex 2 beta subunit; clathrin assembly protein complex 2 beta large chain; plasma membrane adaptor HA2/AP2 adaptin beta subunit; beta-2-adaptin; beta adaptin; adapter-related protein complex 2 subunit beta; adaptor-related protein complex 2 subunit beta; AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291}
Gene NamesAp2b1; rCG_33026 {ECO:0000313|EMBL:EDM05477.1}; adaptor-related protein complex 2, beta 1 subunit
Gene Locus10q26; chromosome 10
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_542150 NM_080583 140670 Q3ZB97 N/A N/A N/A rno:140670

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 951 aa

Average Mass: 105.691 kDa

Monoisotopic Mass: 105.625 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
non-SMC mitotic condensation complex subunit 1 1. 1564105.00.3
Guanine nucleotide exchange factor in Golgi transport N-terminal 1. 6899109.00.0
CLASP N terminal 1. 121151177.00.2
CLASP N terminal 2. 163193180.00.0
Armadillo-like 1. 24030498.00.1
CLASP N terminal 3. 38243386.00.1
CLASP N terminal 4. 489532118.00.0
--- cleavage 691 ---
Adaptin C-terminal domain 1. 7358309.00.4
Guanine nucleotide exchange factor in Golgi transport N-terminal 2. 932947135.00.0

3. Sequence Information

Fasta Sequence: SB0103.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1 and 2

Source Reference: [PubMed ID: 19240038] Rudinskiy N, Grishchuk Y, Vaslin A, Puyal J, Delacourte A, Hirling H, Clarke PG, Luthi-Carter R, Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. J Biol Chem. 2009 May 1;284(18):12447-58. doi: 10.1074/jbc.M804740200. Epub 2009

Cleavage sites (±10aa)


Phe691 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 17022975] Tokumitsu H, Hatano N, Yokokura S, Sueyoshi Y, Nozaki N, Kobayashi R, Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2. FEBS Lett. 2006 Oct 16;580(24):5797-801. Epub 2006 Sep 27.

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