logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0106 : Aggrecan

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Namesaggrecan core protein precursor [Bos taurus]; aggrecan core protein precursor; aggrecan core protein; aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122); aggrecan epidermal growth factor-like domain-1; CSPCP; cartilage-specific proteoglycan core protein
Gene NamesACAN; aggrecan
Gene Locus21; chromosome 21
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_776406 NM_173981 280985 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2327 aa

Average Mass: 242.478 kDa

Monoisotopic Mass: 242.333 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Chordopoxvirus A33R protein 1. 149183102.00.0
Chordopoxvirus A33R protein 2. 257283113.00.0
Domain of unknown function 1. 35040336.00.0
--- cleavage 365 (inside Domain of unknown function 350..403) ---
--- cleavage 474 ---
Chordopoxvirus A33R protein 3. 499517119.00.0
Chordopoxvirus A33R protein 4. 594624116.00.0
--- cleavage 719 ---
Immunoglobulin V-set domain 1. 2051208227.00.0
Chordopoxvirus A33R protein 5. 21222153106.00.0
Sushi repeat (SCR repeat) 1. 224423001.00.6

3. Sequence Information

Fasta Sequence: SB0106.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 15175011] Oshita H, Sandy JD, Suzuki K, Akaike A, Bai Y, Sasaki T, Shimizu K, Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain. Biochem J. 2004 Aug 15;382(Pt 1):253-9.

Cleavage sites (±10aa)


Gly365 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ala474 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ala719 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24032649] Ciechomska M, Wilson CL, Floudas A, Hui W, Rowan AD, van Eden W, Robinson JH, Knight AM, Antigen-specific B lymphocytes acquire proteoglycan aggrecan from cartilage extracellular matrix resulting in antigen presentation and CD4+ T-cell activation. Immunology. 2014 Jan;141(1):70-8. doi: 10.1111/imm.12169.

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