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SB0107 : Aggrecan

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein NamesRecName: Full=Aggrecan core protein; AltName: Full=Cartilage-specific proteoglycan core protein; Short=CSPCP; AltName: Full=Chondroitin sulfate proteoglycan core protein 1; Short=Chondroitin sulfate proteoglycan 1; Contains: RecName: Full=Aggrecan core protein 2; Flags: Precursor; Aggrecan core protein; Cartilage-specific proteoglycan core protein; Chondroitin sulfate proteoglycan core protein 1; CSPCP; Chondroitin sulfate proteoglycan 1; Aggrecan core protein 2
Gene NamesAGC1, CSPG1, MSK16; AGC1; CSPG1; MSK16
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P16112 N/A N/A P16112 N/A N/A N/A hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2415 aa

Average Mass: 250.190 kDa

Monoisotopic Mass: 250.040 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Immunoglobulin I-set domain 1. 11415054.00.0
Lectin C-type domain 1. 1671874.00.0
Human growth factor-like EGF 1. 1982033.00.1
Lectin C-type domain 2. 2642833.00.0
Lectin C-type domain 3. 4905122.00.0
Human growth factor-like EGF 2. 5235283.00.1
Lectin C-type domain 4. 5896043.00.1
--- cleavage 709 ---
Human growth factor-like EGF 3. 151115175.00.1
Human growth factor-like EGF 4. 168816936.00.1
Immunoglobulin V-set domain 1. 2089214611.00.0
Nematode antimicrobial peptide 1. 2164218918.02.8
Extracellular link domain 1. 2226224316.00.0
Sushi repeat (SCR repeat) 1. 233223881.01.3

3. Sequence Information

Fasta Sequence: SB0107.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 4MD4 (X-ray; 195 A; C=89-103)

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 15175011] Oshita H, Sandy JD, Suzuki K, Akaike A, Bai Y, Sasaki T, Shimizu K, Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain. Biochem J. 2004 Aug 15;382(Pt 1):253-9.

Cleavage sites (±10aa)


Ala709 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 1985970] Doege KJ, Sasaki M, Kimura T, Yamada Y, Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. J Biol Chem. 1991 Jan 15;266(2):894-902.

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