logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0108 : Aggrecan

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesaggrecan core protein precursor [Rattus norvegicus]; aggrecan core protein precursor; aggrecan core protein; CSPCP; cartilage-specific proteoglycan core protein; aggrecan 1; aggrecan, structural proteoglycan of cartilage
Gene NamesAcan; aggrecan
Gene Locus1q31; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_071526 NM_022190 58968 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2162 aa

Average Mass: 225.237 kDa

Monoisotopic Mass: 225.102 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Chordopoxvirus A33R protein 1. 150183103.00.0
Chordopoxvirus A33R protein 2. 257283113.00.0
Domain of unknown function 1. 35039936.00.0
Chordopoxvirus A33R protein 3. 499518119.00.0
Chordopoxvirus A33R protein 4. 593625115.00.1
EGF-like domain 1. 6786858.00.0
--- cleavage 715 ---
EGF-like domain 2. 191419431.01.1
Chordopoxvirus A33R protein 5. 19581988107.00.0
Sushi repeat (SCR repeat) 1. 207921351.00.7

3. Sequence Information

Fasta Sequence: SB0108.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 15175011] Oshita H, Sandy JD, Suzuki K, Akaike A, Bai Y, Sasaki T, Shimizu K, Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain. Biochem J. 2004 Aug 15;382(Pt 1):253-9.

Cleavage sites (±10aa)


Asp715 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 22961837] Zhang Y, Ross AC, Retinoic acid and the transcription factor MafB act together and differentially to regulate aggrecan and matrix metalloproteinase gene expression in neonatal chondrocytes. J Cell Biochem. 2013 Feb;114(2):471-9. doi: 10.1002/jcb.24387.

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