logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0113 : Paxillin

[ CaMP Format ]

* Basic Information

OrganismGallus gallus (chicken)
Protein Namespaxillin [Gallus gallus]; paxillin; Paxillin
Gene NamesPXN; paxillin
Gene Locus15; chromosome 15
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_990315 NM_204984 395832 P49024 N/A N/A N/A gga:395832

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 559 aa

Average Mass: 61.242 kDa

Monoisotopic Mass: 61.203 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 96 ---
EAP30/Vps36 family 1. 2473108.00.0
Ribosomal protein L37e 1. 3393575.00.1
Protein of unknown function (DUF1797) 1. 35937916.00.0
Ribosomal protein L37e 2. 40241525.00.0
Protein of unknown function (DUF1797) 2. 48249920.00.0
Ribosomal protein L37e 3. 5165345.01.7

3. Sequence Information

Fasta Sequence: SB0113.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2L6F (NMR; -; A=140-161, A=262-275), 2L6G (NMR; -; A=140-161), 2L6H (NMR; -; A=263-276), 4R32 (X-ray; 350 A; B/C=139-162)

* Cleavage Information

1 [sites] cleaved by Calpain 1 or 2

Source Reference: [PubMed ID: 21270128] Cortesio CL, Boateng LR, Piazza TM, Bennin DA, Huttenlocher A, Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration. J Biol Chem. 2011 Mar 25;286(12):9998-10006. doi: 10.1074/jbc.M110.187294. Epub

Cleavage sites (±10aa)


Ser96 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 18092823] Bertolucci CM, Guibao CD, Zheng JJ, Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase. Biochemistry. 2008 Jan 15;47(2):548-54. Epub 2007 Dec 20.

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