logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0114 : Filaggrin

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesfilaggrin-2 [Homo sapiens]; filaggrin-2; filaggrin 2; ifapsoriasin; intermediate filament-associated and psoriasis susceptibility protein; FLG-2; intermediate filament-associated and psoriasis-susceptibility protein; Filaggrin-2; Intermediate filament-associated and psoriasis-susceptibility protein; Ifapsoriasin
Gene NamesFLG2; IFPS; filaggrin family member 2
Gene Locus1q21.3; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001014364 NM_001014342 388698 Q5D862 616284 HGNC:33276 11815 hsa:388698

* Information From OMIM

Description: The FLG2 gene encodes a member of the S100 fused-type protein (SFTP) family. These proteins are essential components that maintain epithelial homeostasis and barrier function (summary by Wu et al., 2009).

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* Structure Information

1. Primary Information

Length: 2391 aa

Average Mass: 248.070 kDa

Monoisotopic Mass: 247.928 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
EF hand 1. 263915.00.0
EF hand 2. 54802.00.5
EF-hand domain pair 1. 9210923.00.1

3. Sequence Information

Fasta Sequence: SB0114.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 21531719] Hsu CY, Henry J, Raymond AA, Mechin MC, Pendaries V, Nassar D, Hansmann B, Balica S, Burlet-Schiltz O, Schmitt AM, Takahara H, Paul C, Serre G, Simon M, Deimination of human filaggrin-2 promotes its proteolysis by calpain 1. J Biol Chem. 2011 Jul 1;286(26):23222-33. doi: 10.1074/jbc.M110.197400. Epub 2011

Cleavage sites (±10aa)


Thr1713 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ser1741 His

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


His1771 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ser1788 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24813994] Makino T, Mizawa M, Yamakoshi T, Takaishi M, Shimizu T, Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin. Biochem Biophys Res Commun. 2014 Jun 20;449(1):100-6. doi:

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