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SB0115 : Selenoprotein K

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namesselenoprotein K [Mus musculus]; selenoprotein K; heat shock protein, 30 kDa; Selenoprotein K; SelK
Gene NamesSelk; selenoprotein K
Gene Locus14; chromosome 14
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_064363 NM_019979 80795 Q9JLJ1 N/A N/A N/A mmu:80795

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 94 aa

Average Mass: 10.642 kDa

Monoisotopic Mass: 10.636 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Protein of unknown function (DUF2763) 1. 2911.00.5
--- cleavage 81 (inside Protein of unknown function (DUF2763) 2..91) ---

3. Sequence Information

Fasta Sequence: SB0115.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 21849499] Huang Z, Hoffmann FW, Norton RL, Hashimoto AC, Hoffmann PR, Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages. J Biol Chem. 2011 Oct 7;286(40):34830-8. doi: 10.1074/jbc.M111.265520. Epub 2011

Cleavage sites (±10aa)


Arg81 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23444136] Meiler S, Baumer Y, Huang Z, Hoffmann FW, Fredericks GJ, Rose AH, Norton RL, Hoffmann PR, Boisvert WA, Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J Leukoc Biol. 2013 May;93(5):771-80. doi: 10.1189/jlb.1212647. Epub 2013 Feb 26.

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