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SB0116 : Vesicular glutamate transporter 2

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesvesicular glutamate transporter 2 [Rattus norvegicus]; vesicular glutamate transporter 2; differentiation-associated BNPI; solute carrier family 17 member 6; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; differentation-associated Na-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6
Gene NamesSlc17a6; Dnpi, Vglut2; Dnpi; Vglut2; solute carrier family 17 (vesicular glutamate transporter), member 6
Gene Locus1q22; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_445879 NM_053427 84487 Q9JI12 N/A N/A N/A rno:84487

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 582 aa

Average Mass: 64.575 kDa

Monoisotopic Mass: 64.534 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
BT1 family 1. 8815595.00.1
BT1 family 2. 220266131.00.0
Major Facilitator Superfamily 1. 446513123.00.1

3. Sequence Information

Fasta Sequence: SB0116.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 21807096] Lobo AC, Gomes JR, Catarino T, Mele M, Fernandez P, Inacio AR, Bahr BA, Santos AE, Wieloch T, Carvalho AL, Duarte CB, Cleavage of the vesicular glutamate transporters under excitotoxic conditions. Neurobiol Dis. 2011 Dec;44(3):292-303. doi: 10.1016/j.nbd.2011.07.010. Epub 2011

Cleavage sites (±10aa)


Gln533 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Thr541 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23543101] Kiss J, Csaba Z, Csaki A, Halasz B, Demonstration of estrogen receptor alpha protein in glutamatergic (vesicular glutamate transporter 2 immunoreactive) neurons of the female rat hypothalamus and amygdala using double-label immunocytochemistry. Exp Brain Res. 2013 May;226(4):595-602. doi: 10.1007/s00221-013-3474-8. Epub 2013

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