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SB0117 : Type 1 inositol 1,4,5-triphosphate receptor, InsP3R1

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesinositol 1,4,5-trisphosphate receptor type 1 [Rattus norvegicus]; inositol 1,4,5-trisphosphate receptor type 1; IP-3-R; type 1 InsP3 receptor; IP3 receptor; type 1 inositol 1,4,5-trisphosphate receptor; IP3R 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-triphosphate receptor 1
Gene NamesItpr1; inositol 1,4,5-trisphosphate receptor, type 1
Gene Locus4q41; chromosome 4
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001007236 NM_001007235 25262 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2749 aa

Average Mass: 313.133 kDa

Monoisotopic Mass: 312.937 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
MIR domain 1. 10914460.00.0
Inositol 1,4,5-trisphosphate/ryanodine receptor 1. 236256100.00.0
RyR and IP3R Homology associated 1. 50352522.00.7
RyR and IP3R Homology associated 2. 55858112.00.1
RyR and IP3R Homology associated 3. 1281130850.00.4
RIH domain 1. 14531475156.00.1
RyR and IP3R Homology associated 4. 153216836.00.4
--- cleavage 1917 ---
RIH domain 2. 1978199231.00.1
Ion transport protein 1. 22692292200.01.5
Ion transport protein 2. 2354259934.05.3
RyR and IP3R Homology associated 5. 2688272523.00.4

3. Sequence Information

Fasta Sequence: SB0117.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 21859719] Kopil CM, Vais H, Cheung KH, Siebert AP, Mak DO, Foskett JK, Neumar RW, Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. J Biol Chem. 2011 Oct 14;286(41):35998-6010. doi: 10.1074/jbc.M111.254177. Epub

Cleavage sites (±10aa)


Glu1917 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 22286060] Seo MD, Velamakanni S, Ishiyama N, Stathopulos PB, Rossi AM, Khan SA, Dale P, Li C, Ames JB, Ikura M, Taylor CW, Structural and functional conservation of key domains in InsP3 and ryanodine receptors. Nature. 2012 Jan 29;483(7387):108-12. doi: 10.1038/nature10751.

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