logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0123 : Neuronal calcium sensor-1, NCS-1

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesneuronal calcium sensor 1 [Rattus norvegicus]; neuronal calcium sensor 1; NCS-1; frequenin-like protein; frequenin-like ubiquitous protein; Neuronal calcium sensor 1; Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein
Gene NamesNcs1; Flup, Freq; Flup; Freq; neuronal calcium sensor 1
Gene Locus3p12; chromosome 3
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_077342 NM_024366 65153 P62168 N/A N/A N/A rno:65153

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 190 aa

Average Mass: 21.878 kDa

Monoisotopic Mass: 21.865 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
EF-hand domain 1. 235133.00.0
--- cleavage 36 (inside EF-hand domain 23..51) ---
Secreted protein acidic and rich in cysteine Ca binding region 1. 688693.00.1
Caleosin related protein 1. 14617992.00.0

3. Sequence Information

Fasta Sequence: SB0123.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 4OV2 (X-ray; 260 A; A/B/C/D=1-177), 4YRU (X-ray; 280 A; A/B/C/D=1-177), 5AEQ (X-ray; 195 A; A/B=1-190), 5AER (X-ray; 219 A; A=1-190), 5AFP (X-ray; 230 A; A/B=1-190)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 19732951] Blachford C, Celic A, Petri ET, Ehrlich BE, Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding. Cell Calcium. 2009 Oct;46(4):257-62. doi: 10.1016/j.ceca.2009.08.002. Epub 2009

Cleavage sites (±10aa)


Lys36 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 22521426] Drumond LE, Mourao FA, Leite HR, Abreu RV, Reis HJ, Moraes MF, Pereira GS, Massensini AR, Differential effects of swimming training on neuronal calcium sensor-1 expression in rat hippocampus/cortex and in object recognition memory tasks. Brain Res Bull. 2012 Jul 1;88(4):385-91. doi: 10.1016/j.brainresbull.2012.04.005.

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