logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0124 : Actin-binding protein-1, Drebrin-like protein

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namesdrebrin-like protein isoform 1 [Mus musculus]; drebrin-like protein isoform 1; drebrin-like protein; actin-binding protein 1; SH3 domain-containing protein 7; dbnl; Drebrin-like protein; Actin-binding protein 1
Gene NamesDbnl; Abp1 {ECO:0000312|EMBL:AAM28340.1},Sh3p7 {ECO:0000303|PubMed:9630982}; Abp1 {ECO:0000312|EMBL:AAM28340.1}; Sh3p7 {ECO:0000303|PubMed:9630982}; drebrin-like
Gene Locus11 3.87 cM; chromosome 11
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001139780 NM_001146308 13169 Q62418 N/A N/A N/A mmu:13169

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 436 aa

Average Mass: 48.699 kDa

Monoisotopic Mass: 48.670 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
SH3 domain 1. 203024.00.0
RNA polymerase I-specific transcription-initiation factor 1. 184306745.015.5
--- cleavage 283 (inside RNA polymerase I-specific transcription-initiation factor 184..306) ---
--- cleavage 290 (inside RNA polymerase I-specific transcription-initiation factor 184..306) ---
Variant SH3 domain 1. 3824342.00.0

3. Sequence Information

Fasta Sequence: SB0124.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 19910490] Cortesio CL, Perrin BJ, Bennin DA, Huttenlocher A, Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation. Mol Biol Cell. 2010 Jan 1;21(1):186-97. doi: 10.1091/mbc.E09-02-0106. Epub 2009

Cleavage sites (±10aa)


Ser283 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Arg290 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24958882] Seeley-Fallen MK, Liu LJ, Shapiro MR, Onabajo OO, Palaniyandi S, Zhu X, Tan TH, Upadhyaya A, Song W, Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9881-6. doi:

» More (9)