logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0125 : Transient receptor potential canonical 6, TRPC6

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namesshort transient receptor potential channel 6 isoform 1 [Mus musculus]; short transient receptor potential channel 6 isoform 1; short transient receptor potential channel 6; calcium entry channel; transient receptor protein 6; Short transient receptor potential channel 6; TrpC6; Calcium entry channel; Transient receptor protein 6; TRP-6
Gene NamesTrpc6; Trp6, Trrp6; Trp6; Trrp6; transient receptor potential cation channel, subfamily C, member 6
Gene Locus9 2.46 cM; chromosome 9
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_038866 NM_013838 22068 Q61143 N/A N/A N/A mmu:22068

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 930 aa

Average Mass: 106.680 kDa

Monoisotopic Mass: 106.612 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 16 ---
Ankyrin repeats (many copies) 1. 10413923.00.1
Ankyrin repeats (many copies) 2. 22023836.00.0
Inhibitor of growth proteins N-terminal histone-binding 1. 24827142.00.1
Cytochrome b562 1. 30334632.00.0
Polycystin cation channel 1. 490733210.014.0
Inhibitor of growth proteins N-terminal histone-binding 2. 79683047.00.5
Inhibitor of growth proteins N-terminal histone-binding 3. 85392129.01.5

3. Sequence Information

Fasta Sequence: SB0125.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 20811149] Du W, Huang J, Yao H, Zhou K, Duan B, Wang Y, Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats. J Clin Invest. 2010 Oct;120(10):3480-92. doi: 10.1172/JCI43165. Epub 2010 Sep 1.

Cleavage sites (±10aa)


Lys16 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24462772] Albarran L, Berna-Erro A, Dionisio N, Redondo PC, Lopez E, Lopez JJ, Salido GM, Brull Sabate JM, Rosado JA, TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets. Biochim Biophys Acta. 2014 Apr;1843(4):789-96. doi: 10.1016/j.bbamcr.2014.01.014.

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