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SB0126 : OTK18

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Nameszinc finger protein 175 [Homo sapiens]; zinc finger protein 175; zinc finger protein OTK18; Zinc finger protein 175; Zinc finger protein OTK18
Gene NamesZNF175; zinc finger protein 175
Gene Locus19q13.4; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_009078 NM_007147 7728 Q9Y473 601139 HGNC:12964 03088 hsa:7728

* Information From OMIM

Function: Using binding and mutation analyses, Carlson et al. (2004) showed that both the KRAB and zinc finger regions of OTK18 were required for its transcriptional suppressor function. OTK18 was induced in macrophages following HIV-1 infection and restricted viral infection. OTK18-mediated suppression of HIV-1 replication appeared to involve suppression of HIV-1 Tat-induced viral long-terminal repeat promoter activity.

* Structure Information

1. Primary Information

Length: 711 aa

Average Mass: 81.609 kDa

Monoisotopic Mass: 81.557 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
LYAR-type C2HC zinc finger 1. 35439.00.0
YhfH-like protein 1. 19319910.01.0
Adenylate kinase, active site lid 1. 27529117.00.9
C2HE / C2H2 / C2HC zinc-binding finger 1. 30832138.00.3
C2HE / C2H2 / C2HC zinc-binding finger 2. 33435836.01.5
--- cleavage 359 ---
YhfH-like protein 2. 36337213.00.1
C2HE / C2H2 / C2HC zinc-binding finger 3. 39140737.00.4
zinc-ribbon 1. 41842921.00.0
YhfH-like protein 3. 44846015.00.1
C2HE / C2H2 / C2HC zinc-binding finger 4. 47148633.09.5
C2HE / C2H2 / C2HC zinc-binding finger 5. 50051934.01.1
C2HE / C2H2 / C2HC zinc-binding finger 6. 53254238.00.4
C2HE / C2H2 / C2HC zinc-binding finger 7. 55457732.01.5
C2HE / C2H2 / C2HC zinc-binding finger 8. 58459734.01.4
C2HE / C2H2 / C2HC zinc-binding finger 9. 63266126.01.7
C2HE / C2H2 / C2HC zinc-binding finger 10. 66869434.00.4

3. Sequence Information

Fasta Sequence: SB0126.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 19034669] Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T, Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. J Neuroimmune Pharmacol. 2009 Mar;4(1):116-28. doi: 10.1007/s11481-008-9140-4.

Cleavage sites (±10aa)


Arg359 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 22491018] Wang J, Bansal AT, Martin M, Germer S, Benayed R, Essioux L, Lee JS, Begovich A, Hemmings A, Kenwright A, Taylor KE, Upmanyu R, Cutler P, Harari O, Marchini J, Criswell LA, Platt A, Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. Pharmacogenomics J. 2013 Jun;13(3):235-41. doi: 10.1038/tpj.2012.8. Epub 2012 Apr

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