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SB0132 : dUTPase

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesdeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2 [Homo sapiens]; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2; dUTP pyrophosphatase; dUTP nucleotidohydrolase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; dUTP diphosphatase
Gene NamesDUT; deoxyuridine triphosphatase
Gene Locus15q21.1; chromosome 15
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001939 NM_001948 1854 N/A 601266 HGNC:3078 03165 N/A

* Information From OMIM

Description: Deoxyuridine triphosphate nucleotidohydrolase (dUTPase; EC hydrolyzes dUTP to dUMP and pyrophosphate (Ladner and Caradonna, 1997).

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* Structure Information

1. Primary Information

Length: 164 aa

Average Mass: 17.748 kDa

Monoisotopic Mass: 17.737 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 4 ---
--- cleavage 7 ---
--- cleavage 31 ---
dUTPase 1. 341622.00.0

3. Sequence Information

Fasta Sequence: SB0132.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 21625588] Bozoky Z, Rona G, Klement E, Medzihradszky KF, Merenyi G, Vertessy BG, Friedrich P, Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide. PLoS One. 2011;6(5):e19546. doi: 10.1371/journal.pone.0019546. Epub 2011 May 19.

Cleavage sites (±10aa)


Ser4 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Thr7 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Leu31 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24311590] Rona G, Marfori M, Borsos M, Scheer I, Takacs E, Toth J, Babos F, Magyar A, Erdei A, Bozoky Z, Buday L, Kobe B, Vertessy BG, Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2495-505. doi:

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