logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0133 : CAPNS1, 30K, Calpain regulatory subunit

[ CaMP Format ]

* Basic Information

OrganismOryctolagus cuniculus (rabbit)
Protein Namescalpain small subunit 1 [Oryctolagus cuniculus]; calpain small subunit 1; CDPS; CSS1; CANP small subunit; calpain regulatory subunit; calcium-dependent protease small subunit 1; calcium-activated neutral proteinase small subunit; Calpain small subunit 1; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit; Calcium-dependent protease small subunit 1; Calpain regulatory subunit
Gene NamesCAPNS1; CAPN4; calpain, small subunit 1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001075733 NM_001082264 100009090 P06813 N/A N/A N/A ocu:100009090

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 266 aa

Average Mass: 28.238 kDa

Monoisotopic Mass: 28.221 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 89 ---
EF-hand domain pair 1. 11516518.00.1
EF-hand domain pair 2. 17318729.00.0
EF-hand domain 1. 22322918.00.0
EF hand 1. 2392534.00.1

3. Sequence Information

Fasta Sequence: SB0133.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 3023314] Imajoh S, Kawasaki H, Suzuki K, Limited autolysis of calcium-activated neutral protease (CANP): reduction of the Ca2+-requirement is due to the NH2-terminal processing of the large subunit. J Biochem. 1986 Sep;100(3):633-42.

Cleavage sites (±10aa)


Glu89 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 3038855] Minami Y, Emori Y, Kawasaki H, Suzuki K, E-F hand structure-domain of calcium-activated neutral protease (CANP) can bind Ca2+ ions. J Biochem. 1987 Apr;101(4):889-95.

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