logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0134 : Glycogen synthase kinase-3[beta] (GSK-3[beta])

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesglycogen synthase kinase-3 beta [Rattus norvegicus]; glycogen synthase kinase-3 beta; FA; factor A; GSK-3 beta; serine/threonine-protein kinase GSK3B; Glycogen synthase kinase-3 beta;; Factor A; Serine/threonine-protein kinase GSK3B;
Gene NamesGsk3b; glycogen synthase kinase 3 beta
Gene Locus11q21; chromosome 11
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_114469 NM_032080 84027 P18266 N/A N/A N/A rno:84027

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 420 aa

Average Mass: 46.710 kDa

Monoisotopic Mass: 46.681 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 38 ---
ABC1 family 1. 588615.00.0
Phosphotransferase enzyme family 1. 174196165.00.1

3. Sequence Information

Fasta Sequence: SB0134.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 22496446] Ma S, Liu S, Huang Q, Xie B, Lai B, Wang C, Song B, Li M, Site-specific phosphorylation protects glycogen synthase kinase-3beta from calpain-mediated truncation of its N and C termini. J Biol Chem. 2012 Jun 29;287(27):22521-32. doi: 10.1074/jbc.M111.321349. Epub

Cleavage sites (±10aa)


Thr38 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ile384 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24425879] Desai SS, Modali SD, Parekh VI, Kebebew E, Agarwal SK, GSK-3beta protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation. J Biol Chem. 2014 Feb 28;289(9):5386-98. doi: 10.1074/jbc.M113.533612. Epub 2014

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