logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0136 : [beta]-Catenin

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namescatenin beta-1 [Mus musculus]; catenin beta-1; beta-catenin; Catenin beta-1; Beta-catenin
Gene NamesCtnnb1; Catnb; catenin (cadherin associated protein), beta 1
Gene Locus9 72.19 cM; chromosome 9
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001159374 NM_001165902 12387 Q02248 N/A N/A N/A mmu:12387

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 781 aa

Average Mass: 85.470 kDa

Monoisotopic Mass: 85.416 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 28 ---
--- cleavage 29 ---
--- cleavage 30 ---
--- cleavage 95 ---
Kinesin-associated protein (KAP) 1. 153208578.00.1
Domain of unknown function (DUF3361) 1. 23326495.00.3
Armadillo/beta-catenin-like repeat 1. 2723037.00.0
Armadillo/beta-catenin-like repeat 2. 3083281.00.0
Kinesin-associated protein (KAP) 2. 335466305.00.0
Kinesin-associated protein (KAP) 3. 508591308.00.0
Armadillo-like 1. 594647134.00.0

3. Sequence Information

Fasta Sequence: SB0136.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DOW (X-ray; 180 A; B=118-149), 1I7W (X-ray; 200 A; A/C=134-671), 1I7X (X-ray; 300 A; A/C=134-671), 1JPP (X-ray; 310 A; A/B=134-671), 1M1E (X-ray; 210 A; A=134-671), 1V18 (X-ray; 210 A; A=134-671), 2BCT (X-ray; 290 A; A=150-665), 3BCT (X-ray; 210 A; A=193-661), 3OUW (X-ray; 291 A; A=134-671), 3OUX (X-ray; 240 A; A=134-671), 4EV8 (X-ray; 190 A; A=134-671), 4EV9 (X-ray; 210 A; A=134-671), 4EVA (X-ray; 200 A; A/C=134-671), 4EVP (X-ray; 226 A; A=134-671), 4EVT (X-ray; 234 A; A=134-671), 4ONS (X-ray; 280 A; B/D=78-151)

* Cleavage Information

4 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 17270735] Abe K, Takeichi M, NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron. 2007 Feb 1;53(3):387-97.

Cleavage sites (±10aa)


Gln28 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ser29 Tyr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Tyr30 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Arg95 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24590964] Cai SX, Liu AR, He HL, Chen QH, Yang Y, Guo FM, Huang YZ, Liu L, Qiu HB, Stable genetic alterations of beta-catenin and ROR2 regulate the Wnt pathway, affect the fate of MSCs. J Cell Physiol. 2014 Jun;229(6):791-800. doi: 10.1002/jcp.24500.

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