logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0146 : Junctophilin-2

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namesjunctophilin-2 [Mus musculus]; junctophilin-2; junctophilin type 2
Gene NamesJph2; junctophilin 2
Gene Locus2; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_067541 NM_021566 59091 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 696 aa

Average Mass: 74.691 kDa

Monoisotopic Mass: 74.647 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
MORN repeat 1. 14341.06.2
MORN repeat 2. 38591.00.8
MORN repeat 3. 60761.01.7
MORN repeat 4. 821011.02.1
MORN repeat 5. 1061281.03.2
MORN repeat 6. 1291461.01.5
--- cleavage 201 ---
MORN repeat 7. 2853061.00.2
MORN repeat 8. 3083301.00.2
Protein of unknown function (DUF3359) 1. 36641439.010.1

3. Sequence Information

Fasta Sequence: SB0146.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain in vivo

Source Reference: [PubMed ID: 24958777] Wu CY, Chen B, Jiang YP, Jia Z, Martin DW, Liu S, Entcheva E, Song LS, Lin RZ, Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure. J Am Heart Assoc. 2014 Jun 23;3(3):e000527. doi: 10.1161/JAHA.113.000527.

Cleavage sites (±10aa)


Leu201 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23973696] Beavers DL, Wang W, Ather S, Voigt N, Garbino A, Dixit SS, Landstrom AP, Li N, Wang Q, Olivotto I, Dobrev D, Ackerman MJ, Wehrens XH, Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. J Am Coll Cardiol. 2013 Nov 19;62(21):2010-9. doi: 10.1016/j.jacc.2013.06.052.

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