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XSB0193 : protein kinase C, beta isoform 2 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0039

* Basic Information

OrganismHomo sapiens (human)
Protein NamesProtein kinase C beta type; PKC-beta; PKC-B;; protein kinase C; beta isoform 2; beta 1 polypeptide
Gene NamesPRKCB; PKCB, PRKCB1; PKCB; PRKCB1; protein kinase C, beta
Gene Locus16p11.2; chromosome 16
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_002729 NM_002738 5579 P05771 176970 9395 N/A hsa:5579

* Information From OMIM

Description: PRKCB1 is a member of the protein kinase C (PKC) gene family (see Coussens et al., 1986 and PRKCA; OMIM:176960).

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* Structure Information

1. Primary Information

Length: 673 aa

Average Mass: 77.012 kDa

Monoisotopic Mass: 76.962 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
C1_1 1. 378980.18.2e-21
C1_1 2. 10215497.35.4e-26
C2 1. 173260126.77.5e-35
--- cleavage 311 ---
Pkinase 1. 342600262.21.2e-75
Pkinase_C 1. 62066555.61.9e-13

3. Sequence Information

Fasta Sequence: XSB0193.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2I0E (X-ray; 260 A; A/B=321-661)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


Ser311 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19168795] Holler C, Pinon JD, Denk U, Heyder C, Hofbauer S, Greil R, Egle A, PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. Blood. 2009 Mar 19;113(12):2791-4. Epub 2009 Jan 23.

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