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XSB1246 : protein kinase C, alpha [Bos taurus]

[ CaMP Format ]

This entry is computationally expanded from SB0055

* Basic Information

OrganismBos taurus (cattle)
Protein NamesProtein kinase C alpha type; PKC-alpha; PKC-A;; protein kinase C; alpha; protein kinase; C alpha
Gene NamesPRKCA; protein kinase C, alpha
Gene Locus19; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_776860 NM_174435 282001 P04409 N/A N/A N/A bta:282001

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 672 aa

Average Mass: 76.837 kDa

Monoisotopic Mass: 76.787 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
C1_1 1. 378983.86e-22
C1_1 2. 10215492.51.5e-24
C2 1. 173260129.01.5e-35
--- cleavage 316 ---
--- cleavage 309 ---
--- cleavage 324 ---
Pkinase 1. 339597288.91.1e-83
Pkinase_C 1. 61766255.81.6e-13

3. Sequence Information

Fasta Sequence: XSB1246.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)


Lys316 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Lys309 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Arg324 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 18977358] Venardos K, Enriquez C, Marshall T, Chin-Dusting JP, Ahlers B, Kaye DM, Protein kinase C mediated inhibition of endothelial L-arginine transport is mediated by MARCKS protein. J Mol Cell Cardiol. 2009 Jan;46(1):86-92. Epub 2008 Oct 14.

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