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XSB1478 : Chain A, Crystal Structure Of A DictyosteliumTETRAHYMENA CHIMERA Actin (Mutant 646: Q228kT229AA230YA231KS232EE360H) IN Complex With Human Gelsolin Segment 1

[ CaMP Format ]

This entry is computationally expanded from SB0031

* Basic Information

Organismsynthetic construct
Protein NamesMajor actin; Actin-1; Actin-2; Actin-2-sub 1; Actin-4; Actin-5; Actin-6; Actin-7; Actin-8; Actin A8; Actin-IEL1; Actin-9; Actin-11; Actin-12; Actin A12; Actin-13; Actin-14; Actin-15; Actin A1; Actin III; Actin-3a; Actin-16; Actin M6; Actin-19; Actin-20; Actin-21
Gene NamesDDB_G0274561; act1a
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1DEJ_A N/A N/A P07830 N/A N/A N/A ddi:DDB_0220456

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 375 aa

Average Mass: 0.000 kDa

Monoisotopic Mass: 0.000 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Actin 1. 2375831.26.5e-247
--- cleavage 37 (inside Actin 2..375) ---

3. Sequence Information

Fasta Sequence: XSB1478.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1C0F (X-ray; 240 A; A=2-375), 1C0G (X-ray; 200 A; A=2-375), 1DEJ (X-ray; 240 A; A=2-375), 1NLV (X-ray; 180 A; A=2-376), 1NM1 (X-ray; 180 A; A=2-376), 1NMD (X-ray; 190 A; A=2-376), 3CHW (X-ray; 230 A; A=2-376), 3CI5 (X-ray; 170 A; A=2-376), 3CIP (X-ray; 160 A; A=2-376)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


Arg37 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 8395021] McLaughlin PJ, Gooch JT, Mannherz HG, Weeds AG, Structure of gelsolin segment 1-actin complex and the mechanism of filament severing. Nature. 1993 Aug 19;364(6439):685-92.

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