logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2184 : Titin [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0101

* Basic Information

OrganismHomo sapiens (human)
Protein NamesTitin; 2.7.11.1; Connectin; Rhabdomyosarcoma antigen MU-RMS-40.14
Gene NamesTTN
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAD12456 N/A N/A TITIN_HUMAN N/A 12403 N/A hsa:7273

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 34350 aa

Average Mass: 3816.218 kDa

Monoisotopic Mass: 3813.840 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
I-set 1. 697137.63.8e-38
I-set 2. 104193116.96.8e-32
Extensin_2 1. 245302-7.77.1
Titin_Z 1. 41345534.44.4e-07
Titin_Z 2. 46450549.51.3e-11
Titin_Z 3. 51054940.66.1e-09
Titin_Z 4. 55259361.14.2e-15
Titin_Z 5. 59863969.01.8e-17
Titin_Z 6. 64468551.43.5e-12
Titin_Z 7. 69073213.80.079
ATP_sub_h 1. 846897-37.69.5
I-set 3. 9431032114.73.1e-31
I-set 4. 1082117385.32.2e-22
Motilin_ghrelin 1. 120612327.14.4
I-set 5. 1291138167.16.7e-17
I-set 6. 1457154796.21.2e-25
I-set 7. 1556164760.09e-15
I-set 8. 1703179449.81e-11
DUF1136 1. 18001827-5.06.4
I-set 9. 1841192990.08.6e-24
I-set 10. 2078216872.91.2e-18
I-set 11. 2174226236.11.4e-07
I-set 12. 2267235326.93.1e-05
I-set 13. 2356244218.30.00015
I-set 14. 2445253050.75.5e-12
I-set 15. 2533261725.93.8e-05
I-set 16. 2620270414.40.0003
I-set 17. 2707279226.43.4e-05
I-set 18. 2795287965.02.7e-16
I-set 19. 2882296647.07.5e-11
I-set 20. 2969305333.96.4e-07
I-set 21. 3058314262.51.6e-15
I-set 22. 3147323311.00.00055
I-set 23. 32393328106.59.1e-29
I-set 24. 33453433124.43.8e-34
I-set 25. 3503359294.53.7e-25
I-set 26. 36213711105.41.9e-28
UPF0181 1. 37623808-16.26.3
Nop10p 1. 39053940-16.14.1
PPAK 1. 403540620.549
Extensin_1 1. 420042090.42e
I-set 27. 4289437749.51.3e-11
I-set 28. 4383447297.45e-26
I-set 29. 4478456785.51.9e-22
I-set 30. 45714660106.87.6e-29
I-set 31. 4664475484.92.8e-22
I-set 32. 4758484769.41.3e-17
I-set 33. 4851494095.81.5e-25
I-set 34. 4944503383.38.6e-22
I-set 35. 5040512998.72.1e-26
I-set 36. 5133522279.71e-20
I-set 37. 5226531697.15.9e-26
I-set 38. 5320540975.02.8e-19
I-set 39. 5413550259.41.4e-14
I-set 40. 5506559562.21.9e-15
I-set 41. 56025691101.43e-27
I-set 42. 5695578474.15.1e-19
I-set 43. 5788587899.71e-26
I-set 44. 58825971103.19.2e-28
I-set 45. 5975606476.21.2e-19
I-set 46. 6068615799.01.6e-26
I-set 47. 6164625377.54.7e-20
I-set 48. 6257634668.23.1e-17
I-set 49. 6350644089.71e-23
I-set 50. 64446533103.38.4e-28
I-set 51. 6537662777.16.4e-20
I-set 52. 66316720111.52.7e-30
I-set 53. 6727681695.12.5e-25
I-set 54. 6820690991.52.9e-24
I-set 55. 6913700254.34.7e-13
I-set 56. 70067095119.61e-32
I-set 57. 7102719175.71.7e-19
I-set 58. 71987287129.89e-36
I-set 59. 72917381111.52.8e-30
I-set 60. 73857474133.09.3e-37
I-set 61. 7478756880.85.1e-21
I-set 62. 7572766195.91.4e-25
I-set 63. 76687757102.12e-27
I-set 64. 7761785084.73.2e-22
I-set 65. 7854794373.95.8e-19
I-set 66. 79478036103.19.6e-28
I-set 67. 8043813278.81.9e-20
I-set 68. 81398228116.59.1e-32
I-set 69. 8232832292.21.8e-24
I-set 70. 8326841589.31.4e-23
I-set 71. 8419850991.13.8e-24
I-set 72. 85138602110.17.5e-30
I-set 73. 86098698108.22.7e-29
I-set 74. 87028791101.23.6e-27
I-set 75. 8795888481.82.5e-21
I-set 76. 88888977126.77.3e-35
I-set 77. 89849073102.71.3e-27
I-set 78. 90809169128.71.9e-35
I-set 79. 9176926674.34.6e-19
I-set 80. 92739362115.22.1e-31
I-set 81. 9381947179.71e-20
--- cleavage 9433 (inside I-set 9381..9471) ---
Nuc_rec_co-act 1. 94989544-0.25
I-set 82. 9583966932.81.3e-06
I-set 83. 9672975653.21e-12
I-set 84. 9761985068.23e-17
Extensin_1 2. 10106101151.11.2e
PPAK 2. 10131101566.14.6
PPAK 3. 10157101843.315
PPAK 4. 101851021124.30.00049
PPAK 5. 102121023818.80.02
PPAK 6. 102391026630.47.2e-06
PPAK 7. 102671029433.49.3e-07
PPAK 8. 102951032135.71.9e-07
PPAK 9. 103221034719.80.011
PPAK 10. 103501037723.80.00071
PPAK 11. 10378104117.32.7
PPAK 12. 104501047615.10.094
PPAK 13. 105031053034.54.3e-07
PPAK 14. 105311055827.65e-05
PPAK 15. 105601058628.13.6e-05
PPAK 16. 105871061428.82.1e-05
PPAK 17. 106151064231.33.8e-06
PPAK 18. 107371076117.00.043
PPAK 19. 107621078831.34e-06
PPAK 20. 107931081825.10.00028
PPAK 21. 10819108474.78.1
PPAK 22. 108741090027.84.5e-05
PPAK 23. 109011092628.23.4e-05
PPAK 24. 109271095438.42.8e-08
PPAK 25. 109551098234.83.4e-07
PPAK 26. 109831101035.91.6e-07
PPAK 27. 111111113411.00.55
PPAK 28. 111351115920.20.0086
PPAK 29. 111921121713.30.21
PPAK 30. 112181124110.30.75
PPAK 31. 112421126520.00.01
PPAK 32. 11266112883.514
PPAK 33. 11365113926.24.3
PPAK 34. 113931141723.10.0011
PPAK 35. 114181144719.20.016
PPAK 36. 114481147528.82.3e-05
PPAK 37. 114761150330.76.1e-06
PPAK 38. 115041153125.00.00031
PPAK 39. 115321155924.20.00054
PPAK 40. 115601158728.43e-05
PPAK 41. 116161164316.80.047
PPAK 42. 116441167132.22.1e-06
PPAK 43. 116721169728.13.5e-05
PPAK 44. 116981172534.54.3e-07
PPAK 45. 11726117502.620
PPAK 46. 117621178727.17.1e-05
I-set 85. 120421213444.44.5e-10
ig 1. 121541221310.10.52
I-set 86. 123241240817.20.00018
I-set 87. 124131249620.79.6e-05
I-set 88. 125011258550.37.3e-12
I-set 89. 125901267349.51.3e-11
I-set 90. 12678127629.60.00071
I-set 91. 127671285127.72.7e-05
I-set 92. 128561294036.79.6e-08
I-set 93. 129451302928.72.3e-05
I-set 94. 130341311821.58.3e-05
I-set 95. 131231320735.62e-07
I-set 96. 132121329652.02.3e-12
I-set 97. 133011338528.22.5e-05
ig 2. 134041346341.04.7e-09
I-set 98. 134791356354.34.7e-13
I-set 99. 135671365636.61e-07
I-set 100. 136611374539.91e-08
I-set 101. 137501383440.94.9e-09
I-set 102. 138391392328.42.4e-05
I-set 103. 139271401346.21.3e-10
fn3 1. 140171410348.52.5e-11
fn3 2. 141181420484.44e-22
fn3 3. 142191430580.85e-21
I-set 104. 143201441119.50.00012
fn3 4. 144151450077.83.9e-20
fn3 5. 145151460080.27.5e-21
I-set 105. 146151470765.81.6e-16
fn3 6. 147111479655.52e-13
fn3 7. 148101489662.51.5e-15
fn3 8. 149111499678.32.8e-20
fn3 9. 150111509674.83.1e-19
fn3 10. 151111519751.53.3e-12
fn3 11. 152121529967.45.2e-17
I-set 106. 153141540387.74e-23
fn3 12. 154071549254.63.7e-13
fn3 13. 155071559382.02.1e-21
I-set 107. 156081572525.64e-05
fn3 14. 157291581662.02.3e-15
fn3 15. 158301591569.11.7e-17
fn3 16. 159291601580.08.5e-21
I-set 108. 160311612042.71.5e-09
fn3 17. 161241620841.33.7e-09
fn3 18. 162221630877.35.5e-20
I-set 109. 163261642155.52e-13
fn3 19. 164251650964.34.6e-16
fn3 20. 165261661761.63e-15
fn3 21. 166321672077.06.6e-20
I-set 110. 167371683525.63.9e-05
fn3 22. 168391692459.99.7e-15
fn3 23. 169391703068.62.3e-17
I-set 111. 170451714051.14.2e-12
fn3 24. 171441723067.74.4e-17
fn3 25. 172441733476.87.8e-20
fn3 26. 173481743475.12.6e-19
I-set 112. 174511753944.83.3e-10
fn3 27. 175431762949.61.2e-11
fn3 28. 176441773073.29.7e-19
I-set 113. 177451783541.92.5e-09
fn3 29. 178391792263.57.7e-16
fn3 30. 179391802572.31.8e-18
fn3 31. 180401812883.95.9e-22
I-set 114. 181451823363.11.1e-15
fn3 32. 182371832251.92.5e-12
fn3 33. 183371842173.76.9e-19
I-set 115. 184371852783.67.1e-22
fn3 34. 185311861765.61.9e-16
fn3 35. 186311871679.21.4e-20
fn3 36. 187311881852.22e-12
I-set 116. 188351892553.58.3e-13
fn3 37. 189291901351.82.6e-12
fn3 38. 190281911141.92.6e-09
I-set 117. 191281922069.81e-17
fn3 39. 192241930956.41.1e-13
fn3 40. 193231940966.97.3e-17
fn3 41. 194241951664.54e-16
I-set 118. 195331962231.05e-06
fn3 42. 196261971186.11.2e-22
fn3 43. 197261981282.31.8e-21
I-set 119. 198271991560.66.1e-15
fn3 44. 199192000259.99.5e-15
fn3 45. 200192010566.21.2e-16
fn3 46. 201162020549.21.6e-11
I-set 120. 202222031272.21.9e-18
fn3 47. 203162040163.11.1e-15
fn3 48. 204152050172.61.4e-18
fn3 49. 205162060380.18e-21
I-set 121. 206202071031.92.7e-06
fn3 50. 207142079972.41.6e-18
fn3 51. 208112089464.54e-16
LSPR 1. 20904209121.22e
I-set 122. 209212099944.54.1e-10
fn3 52. 210032109158.23.2e-14
fn3 53. 211032118971.33.6e-18
fn3 54. 212002128864.54e-16
I-set 123. 213032139651.43.6e-12
fn3 55. 214002148560.18.2e-15
fn3 56. 214992158589.89.4e-24
fn3 57. 216002168769.31.5e-17
I-set 124. 217032179147.55.3e-11
fn3 58. 217952188059.61.2e-14
fn3 59. 218922197679.31.4e-20
I-set 125. 219922208232.31.9e-06
fn3 60. 220862217262.91.2e-15
fn3 61. 221862227274.83.2e-19
fn3 62. 222832237155.71.8e-13
I-set 126. 223882247855.22.6e-13
fn3 63. 224822256852.31.9e-12
fn3 64. 225822266865.32.3e-16
fn3 65. 226832277069.41.3e-17
I-set 127. 227872287532.91.3e-06
fn3 66. 228792296466.21.2e-16
fn3 67. 229762306078.81.9e-20
I-set 128. 230752316476.21.2e-19
fn3 68. 231682325157.93.9e-14
fn3 69. 232682335455.61.9e-13
fn3 70. 233652345367.74.2e-17
I-set 129. 234682356064.15.3e-16
fn3 71. 235642365055.61.9e-13
fn3 72. 236642375061.72.8e-15
fn3 73. 237652385253.67.4e-13
I-set 130. 238692395743.58.5e-10
fn3 74. 239612404666.21.2e-16
fn3 75. 240582414277.06.6e-20
I-set 131. 241572424559.41.3e-14
fn3 76. 242502433368.03.6e-17
fn3 77. 243502443664.24.7e-16
fn3 78. 244472453560.18.2e-15
I-set 132. 245562464269.51.3e-17
fn3 79. 246462473260.85.2e-15
fn3 80. 247462483273.01.1e-18
fn3 81. 248472493468.72.2e-17
I-set 133. 249512503947.94e-11
fn3 82. 250432512845.02.9e-10
fn3 83. 251402522479.11.6e-20
I-set 134. 252392532875.42.1e-19
fn3 84. 253322541565.32.3e-16
fn3 85. 254322551854.34.5e-13
fn3 86. 255292561774.05.4e-19
I-set 135. 256342572546.51.1e-10
fn3 87. 257292581560.18.5e-15
fn3 88. 258292591572.41.7e-18
fn3 89. 259302601768.72.2e-17
I-set 136. 260342612232.31.9e-06
fn3 90. 261262621171.33.5e-18
fn3 91. 262232630788.42.5e-23
I-set 137. 263222641151.82.6e-12
fn3 92. 264152650061.43.4e-15
fn3 93. 265142660058.72.2e-14
fn3 94. 266112669966.01.4e-16
I-set 138. 267162680650.85.4e-12
fn3 95. 268102689643.11.1e-09
fn3 96. 269102699677.06.9e-20
fn3 97. 270112709687.16.4e-23
I-set 139. 271132720151.82.7e-12
fn3 98. 272052729068.91.8e-17
fn3 99. 273022738676.69.1e-20
I-set 140. 274012749317.00.00019
fn3 100. 274972758062.21.9e-15
fn3 101. 275972768355.91.5e-13
fn3 102. 276952778274.83.2e-19
I-set 141. 277972788947.17.1e-11
fn3 103. 278932797948.03.8e-11
fn3 104. 279932807963.86.6e-16
fn3 105. 280942818179.61.1e-20
I-set 142. 281982828962.12.1e-15
fn3 106. 282932837839.61.3e-08
fn3 107. 283902847152.21.9e-12
I-set 143. 284902858029.51.4e-05
fn3 108. 285842867060.85.2e-15
fn3 109. 286842877074.83.1e-19
fn3 110. 287812886870.75.3e-18
I-set 144. 288852897559.71.1e-14
fn3 111. 289792906536.41.2e-07
fn3 112. 290792916676.59.7e-20
fn3 113. 291812926770.56e-18
I-set 145. 292842937250.09.5e-12
fn3 114. 293762946159.61.2e-14
fn3 115. 294732955767.35.8e-17
I-set 146. 295742966454.54e-13
fn3 116. 296682975447.17e-11
fn3 117. 297682985457.16.6e-14
fn3 118. 298652995658.91.9e-14
I-set 147. 299733006445.62e-10
fn3 119. 300683015347.36e-11
fn3 120. 301673025463.58.1e-16
fn3 121. 302693035674.63.7e-19
I-set 148. 303733046168.03.4e-17
fn3 122. 304653055045.52.1e-10
fn3 123. 305623064870.46.5e-18
I-set 149. 306653075544.63.8e-10
fn3 124. 307593084565.81.6e-16
fn3 125. 308593094572.61.4e-18
fn3 126. 309603104685.02.6e-22
I-set 150. 310633115135.22.6e-07
fn3 127. 311553123853.29.9e-13
fn3 128. 312563134377.64.5e-20
fn3 129. 313583144472.12e-18
I-set 151. 3146031549102.51.4e-27
I-set 152. 31553316468.10.00092
fn3 130. 316503173451.53.3e-12
fn3 131. 317523183861.14.1e-15
I-set 153. 318553194684.73.3e-22
I-set 154. 319553204540.28.2e-09
fn3 132. 320493213364.93.1e-16
Pkinase 1. 3217832432202.89e-58
I-set 155. 324953258532.12.3e-06
I-set 156. 3261732709102.61.3e-27
I-set 157. 327223281290.56e-24
CwfJ_C_2 1. 3282132902-35.58.2
I-set 158. 333013339051.92.4e-12
LSPR 2. 33410334180.72.9e
I-set 159. 3348833577133.76e-37
I-set 160. 336453373341.43.5e-09
I-set 161. 3377933868107.54.4e-29
I-set 162. 339663405325.93.8e-05
I-set 163. 3406134150123.85.5e-34
I-set 164. 342563434788.81.9e-23

3. Sequence Information

Fasta Sequence: XSB2184.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1BPV (NMR; -; A=22283-22385), 1G1C (X-ray; 210 A; A/B=2073-2171), 1NCT (NMR; -; A=33483-33579), 1NCU (NMR; -; A=33483-33579), 1TIT (NMR; -; A=12677-12765), 1TIU (NMR; -; A=12677-12765), 1TKI (X-ray; 200 A; A/B=32172-32492), 1TNM (NMR; -; A=33489-33579), 1TNN (NMR; -; A=33489-33579), 1WAA (X-ray; 180 A; A/B/C/D=12677-12765, E=12677-12765, F=12677-12765), 1YA5 (X-ray; 244 A; A/B=1-196), 2A38 (X-ray; 200 A; A/B/C=1-194), 2BK8 (X-ray; 169 A; A=32497-32590), 2F8V (X-ray; 275 A; A/B/C/D=1-196), 2ILL (X-ray; 220 A; A=31854-32047), 2J8H (X-ray; 199 A; A=31854-32047), 2J8O (X-ray; 249 A; A/B=31854-32047), 2NZI (X-ray; 290 A; A/B=31854-32155), 3B43 (X-ray; 330 A; A=7945-8511)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] QGGRVFIHQK9433-GDEAKLEIRD

Lys9433 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln9424Gly9425Gly9426Arg9427Val9428Phe9429Ile9430His9431Gln9432Lys9433
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gly9434Asp9435Glu9436Ala9437Lys9438Leu9439Glu9440Ile9441Arg9442Asp9443

Sequence conservation (by blast)

* References

[PubMed ID: 10850961] Freiburg A, Trombitas K, Hell W, Cazorla O, Fougerousse F, Centner T, Kolmerer B, Witt C, Beckmann JS, Gregorio CC, Granzier H, Labeit S, Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity. Circ Res. 2000 Jun 9;86(11):1114-21.

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