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XSB2661 : calpain-2 catalytic subunit [synthetic construct]

[ CaMP Format ]

This entry is computationally expanded from SB0001

* Basic Information

Organismsynthetic construct
Protein Namescalpain-2 catalytic subunit
Gene NamesCAPN2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
BAG10967 N/A N/A N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 79.999 kDa

Monoisotopic Mass: 79.949 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 19 ---
--- cleavage 9 ---
Peptidase_C2 1. 45344800.61e-237
Calpain_III 1. 355510393.63.4e-115
efhand 1. 57660420.40.0074
efhand 2. 60663419.40.015
efhand 3. 6716994.07.6

3. Sequence Information

Fasta Sequence: XSB2661.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] KDREAAEGLG19-SHERAIKYLN

Gly19 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys10Asp11Arg12Glu13Ala14Ala15Glu16Gly17Leu18Gly19
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser20His21Glu22Arg23Ala24Ile25Lys26Tyr27Leu28Asn29

Sequence conservation (by blast)

[Site 2] MAGIAAKLA9-KDREAAEGLG

Ala9 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
-Met1Ala2Gly3Ile4Ala5Ala6Lys7Leu8Ala9
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys10Asp11Arg12Glu13Ala14Ala15Glu16Gly17Leu18Gly19

Sequence conservation (by blast)

* References

[PubMed ID: 18316326] Nagase T, Yamakawa H, Tadokoro S, Nakajima D, Inoue S, Yamaguchi K, Itokawa Y, Kikuno RF, Koga H, Ohara O, Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products. DNA Res. 2008 Jun 30;15(3):137-49. Epub 2008 Mar 2.