logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2671 : calpain 2 [Bos taurus]

[ CaMP Format ]

This entry is computationally expanded from SB0001

* Basic Information

OrganismBos taurus (cattle)
Protein NamesCalpain-2 catalytic subunit; 3.4.22.53; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain; calpain 2; calpain; large polypeptide L2
Gene NamesCAPN2; calpain 2, (m/II) large subunit
Gene Locus16; chromosome 16
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001096556 NM_001103086 281662 CAN2_BOVIN N/A N/A N/A bta:281662

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 79.935 kDa

Monoisotopic Mass: 79.885 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 19 ---
--- cleavage 9 ---
Peptidase_C2 1. 45344808.15.5e-240
Calpain_III 1. 355510387.62.1e-113
efhand 1. 57660420.40.0074
efhand 2. 60663419.40.015
efhand 3. 6716981.614

3. Sequence Information

Fasta Sequence: XSB2671.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] KDREAAEGLG19-SHERAVKYLN

Gly19 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys10Asp11Arg12Glu13Ala14Ala15Glu16Gly17Leu18Gly19
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser20His21Glu22Arg23Ala24Val25Lys26Tyr27Leu28Asn29

Sequence conservation (by blast)

[Site 2] MAGIAAKLA9-KDREAAEGLG

Ala9 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
-Met1Ala2Gly3Ile4Ala5Ala6Lys7Leu8Ala9
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys10Asp11Arg12Glu13Ala14Ala15Glu16Gly17Leu18Gly19

Sequence conservation (by blast)

* References

None.