logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2812 : proMch6 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0042

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCaspase-9; CASP-9;; ICE-like apoptotic protease 6; ICE-LAP6; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; Caspase-9 subunit p35; Caspase-9 subunit p10; proMch6
Gene NamesMch6; MCH6
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAC50776 N/A N/A CASP9_HUMAN N/A N/A N/A hsa:842

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 416 aa

Average Mass: 46.196 kDa

Monoisotopic Mass: 46.166 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CARD 1. 69290.08.3e-24
--- cleavage 115 ---
Peptidase_C14 1. 161413299.66.8e-87
--- cleavage 330 (inside Peptidase_C14 161..413) ---

3. Sequence Information

Fasta Sequence: XSB2812.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1JXQ (X-ray; 280 A; A/B/C/D=140-416), 1NW9 (X-ray; 240 A; B=140-416), 2AR9 (X-ray; 280 A; A/B/C/D=140-416), 3D9T (X-ray; 150 A; C/D=316-321), 3YGS (X-ray; 250 A; P=1-95)

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)


Ile115 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Asp330 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 8900201] Srinivasula SM, Fernandes-Alnemri T, Zangrilli J, Robertson N, Armstrong RC, Wang L, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES, The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem. 1996 Oct 25;271(43):27099-106.