logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2813 : ICE-LAP6

[ CaMP Format ]

This entry is computationally expanded from SB0042

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCaspase-9; CASP-9;; ICE-like apoptotic protease 6; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; Caspase-9 subunit p35; Caspase-9 subunit p10
Gene NamesMCH6
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAC50640 N/A N/A CASP9_HUMAN N/A N/A N/A hsa:842

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 416 aa

Average Mass: 46.323 kDa

Monoisotopic Mass: 46.293 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CARD 1. 69289.89.4e-24
--- cleavage 115 ---
Peptidase_C14 1. 161413304.32.6e-88
--- cleavage 330 (inside Peptidase_C14 161..413) ---

3. Sequence Information

Fasta Sequence: XSB2813.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1JXQ (X-ray; 280 A; A/B/C/D=140-416), 1NW9 (X-ray; 240 A; B=140-416), 2AR9 (X-ray; 280 A; A/B/C/D=140-416), 3D9T (X-ray; 150 A; C/D=316-321), 3YGS (X-ray; 250 A; P=1-95)

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)


Ile115 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Asp330 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 8663294] Duan H, Orth K, Chinnaiyan AM, Poirier GG, Froelich CJ, He WW, Dixit VM, ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996 Jul 12;271(28):16720-4.