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XSB2815 : Chain S, Crystal Structure Of Human M-Calpain Form I

[ CaMP Format ]

This entry is computationally expanded from SB0017

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCalpain small subunit 1; CSS1; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; CDPS; Calpain regulatory subunit; Calcium-activated neutral proteinase small subunit; CANP small subunit
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1KFX_S N/A N/A CPNS1_HUMAN N/A N/A N/A hsa:826

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 184 aa

Average Mass: 21.241 kDa

Monoisotopic Mass: 21.227 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 57 ---
efhand 1. 598718.40.03
efhand 2. 8911716.30.13
efhand 3. 1251520.917
efhand 4. 1541818.22.7

3. Sequence Information

Fasta Sequence: XSB2815.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KFU (X-ray; 250 A; S=85-268), 1KFX (X-ray; 315 A; S=85-268)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


Ile57 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 10666632] Masumoto H, Nakagawa K, Irie S, Sorimachi H, Suzuki K, Bourenkov GP, Bartunik H, Fernandez-Catalan C, Bode W, Strobl S, Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain. Acta Crystallogr D Biol Crystallogr. 2000 Jan;56(Pt 1):73-5.

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