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XSB2816 : Chain B, Crystal Structure Of M-Calpain

[ CaMP Format ]

This entry is computationally expanded from SB0017

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesCalpain small subunit 1; CSS1; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; CDPS; Calpain regulatory subunit; Calcium-activated neutral proteinase small subunit; CANP small subunit
Gene NamesCapn4, Css1; Capn4; Css1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1DF0_B N/A N/A CPNS1_RAT N/A N/A N/A rno:29156

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 184 aa

Average Mass: 21.281 kDa

Monoisotopic Mass: 21.267 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 57 ---
efhand 1. 598718.40.03
efhand 2. 8911715.90.17
efhand 3. 1541817.53.2

3. Sequence Information

Fasta Sequence: XSB2816.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1AJ5 (X-ray; 230 A; A/B=98-270), 1DF0 (X-ray; 260 A; B=88-270), 1DVI (X-ray; 230 A; A/B=88-270), 1NP8 (X-ray; 200 A; A/B=91-249), 1U5I (X-ray; 286 A; B=88-270), 3BOW (X-ray; 240 A; B=88-270), 3DF0 (X-ray; 295 A; B=88-270)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] PDLKTDGFGI57-DTCRSMVAVM

Ile57 Asp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro48Asp49Leu50Lys51Thr52Asp53Gly54Phe55Gly56Ile57
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asp58Thr59Cys60Arg61Ser62Met63Val64Ala65Val66Met67

Sequence conservation (by blast)

* References

[PubMed ID: 9228945] Blanchard H, Grochulski P, Li Y, Arthur JS, Davies PL, Elce JS, Cygler M, Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes. Nat Struct Biol. 1997 Jul;4(7):532-8.

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