logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2826 : Myocilin

[ CaMP Format ]

This entry is computationally expanded from SB0099

* Basic Information

OrganismMacaca fascicularis (crab-eating macaque)
Protein NamesTrabecular meshwork-induced glucocorticoid response protein
Gene NamesTIGR
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
Q863A3 N/A N/A MYOC_MACFA N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 491 aa

Average Mass: 55.513 kDa

Monoisotopic Mass: 55.479 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
M 1. 1201408.99.7
M 2. 1411614.340
--- cleavage 213 ---
OLF 1. 233490490.03.3e-144

3. Sequence Information

Fasta Sequence: XSB2826.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] SELTEVPASR213-ILKESPSGHL

Arg213 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser204Glu205Leu206Thr207Glu208Val209Pro210Ala211Ser212Arg213
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile214Leu215Lys216Glu217Ser218Pro219Ser220Gly221His222Leu223

Sequence conservation (by blast)

* References

[PubMed ID: 11133859] Fingert JH, Clark AF, Craig JE, Alward WL, Snibson GR, McLaughlin M, Tuttle L, Mackey DA, Sheffield VC, Stone EM, Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. Invest Ophthalmol Vis Sci. 2001 Jan;42(1):145-52.