logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2844 : filamin A, alpha isoform 2 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0090

* Basic Information

OrganismHomo sapiens (human)
Protein NamesFilamin-A; Alpha-filamin; Filamin-1; Endothelial actin-binding protein; Actin-binding protein 280; ABP-280; Non-muscle filamin; filamin A; alpha isoform 2; filamin 1
Gene NamesFLNA; FLN, FLN1; FLN; FLN1; filamin A, alpha (actin binding protein 280)
Gene LocusXq28; chromosome X
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001104026 NM_001110556 2316 FLNA_HUMAN 300017 3754 N/A hsa:2316

* Information From OMIM

Description: Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers.

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* Structure Information

1. Primary Information

Length: 2647 aa

Average Mass: 280.739 kDa

Monoisotopic Mass: 280.564 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CH 1. 44149108.91.7e-29
CH 2. 16726999.61.1e-26
Filamin 1. 278371120.45.9e-33
Filamin 2. 378471128.71.9e-35
Filamin 3. 477567133.37.9e-37
Filamin 4. 573660107.35e-29
Filamin 5. 669760148.42.2e-41
Filamin 6. 766863123.95.4e-34
Filamin 7. 869962129.41.1e-35
Filamin 8. 9681058102.91.1e-27
Filamin 9. 10641151158.52e-44
Filamin 10. 11571246134.14.5e-37
Filamin 11. 12521346118.32.6e-32
Filamin 12. 13521439151.82e-42
Filamin 13. 14451536152.99.8e-43
Filamin 14. 15421633147.15.4e-41
Filamin 15. 16391737104.82.8e-28
--- cleavage 1769 ---
Filamin 16. 1773185738.82.2e-08
Filamin 17. 18621949155.81.3e-43
Filamin 18. 1950203625.56.3e-05
Filamin 19. 20442131146.48.8e-41
Filamin 20. 2150222719.00.00025
Filamin 21. 22352322139.88.6e-39
Filamin 22. 2329241791.43.2e-24
Filamin 23. 24262513127.25.4e-35
Filamin 24. 25542643115.32e-31

3. Sequence Information

Fasta Sequence: XSB2844.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2AAV (NMR; -; A=1863-1955), 2BP3 (X-ray; 232 A; A/B=1863-1956), 2BRQ (X-ray; 210 A; A/B=2236-2329), 2J3S (X-ray; 250 A; A/B=2045-2329), 2JF1 (X-ray; 220 A; A=2236-2329), 2K3T (NMR; -; A=2427-2522), 2W0P (X-ray; 190 A; A/B=2236-2329), 3CNK (X-ray; 165 A; A/B=2559-2647)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


Gln1769 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19292868] Motallebipour M, Enroth S, Punga T, Ameur A, Koch C, Dunham I, Komorowski J, Ericsson J, Wadelius C, Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection. FEBS J. 2009 Apr;276(7):1878-90.

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