logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2881 : nonerythroid alpha-spectrin

[ CaMP Format ]

This entry is computationally expanded from SB0061

* Basic Information

OrganismHomo sapiens (human)
Protein NamesSpectrin alpha chain, brain; Spectrin, non-erythroid alpha chain; Alpha-II spectrin; Fodrin alpha chain
Gene NamesSPTAN1; SPTA2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAA51790 N/A N/A SPTA2_HUMAN N/A N/A N/A hsa:6709

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2472 aa

Average Mass: 284.282 kDa

Monoisotopic Mass: 284.107 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Spectrin 1. 44147128.03.1e-35
Spectrin 2. 149253140.26.3e-39
Spectrin 3. 255359139.51e-38
Spectrin 4. 361465115.02.5e-31
Spectrin 5. 467571125.22.2e-34
Spectrin 6. 573676125.41.9e-34
Spectrin 7. 678782146.01.2e-40
Spectrin 8. 784888153.37.5e-43
SH3_1 1. 970102478.91.8e-20
Spectrin 9. 1091123171.62.9e-18
--- cleavage 1176 (inside Spectrin 1091..1231) ---
Spectrin 10. 12331337148.42.2e-41
Spectrin 11. 13391443119.79.5e-33
Spectrin 12. 14451549127.93.3e-35
Spectrin 13. 1551165698.72e-26
Spectrin 14. 16581762130.45.7e-36
Spectrin 15. 17641868146.86.5e-41
Spectrin 16. 18701974124.82.8e-34
Spectrin 17. 19762081121.03.8e-33
Spectrin 18. 2091219572.21.9e-18
Spectrin 19. 2205231068.72.1e-17
efhand 1. 2327235522.50.0017
efhand 2. 2370239823.40.00096
efhand_Ca_insen 1. 2402247140.95e-09

3. Sequence Information

Fasta Sequence: XSB2881.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2FOT (X-ray; 245 A; C=1172-1210), 3FB2 (X-ray; 230 A; A/B=1337-1544)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


Tyr1176 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 2307671] Moon RT, McMahon AP, Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. J Biol Chem. 1990 Mar 15;265(8):4427-33.