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XSB2933 : talin 1 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0081

* Basic Information

OrganismHomo sapiens (human)
Protein NamesTalin-1; talin 1
Gene NamesTLN1; KIAA1027, TLN; KIAA1027; TLN; talin 1
Gene Locus9p13; chromosome 9
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_006280 NM_006289 7094 TLN1_HUMAN 186745 11845 N/A hsa:7094

* Information From OMIM

Description: Talin serves a function of linking vinculin (OMIM:193065) to the integrins, and, thus, the cytoskeleton to extracellular matrix (ECM) receptors. It has a mass of 270 kD and shares 23% N-terminal identity with ezrin (OMIM:123900), which has similar functions.

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* Structure Information

1. Primary Information

Length: 2541 aa

Average Mass: 269.767 kDa

Monoisotopic Mass: 269.599 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM_N 1. 9019999.61.1e-26
FERM_M 1. 201313144.72.8e-40
--- cleavage 433 ---
Talin_middle 1. 491652370.43.2e-108
Stork_head 1. 728795-14.03.2
Inhibitor_I34 1. 840905-11.37.9
PMEI 1. 9461104-11.70.16
DUF1707 1. 11601204-23.63.1
XhlA 1. 13601411-17.47
Mucin 1. 14761614-38.49.2
WSK 1. 163516640.98
HHH 1. 180518340.16.9
VBS 1. 18491973288.71.3e-83
Vir_act_alpha_C 1. 21842262-16.60.79
Wos2 1. 22772322-3.63.1
I_LWEQ 1. 23412533371.91.2e-108

3. Sequence Information

Fasta Sequence: XSB2933.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1SYQ (X-ray; 242 A; B=607-631)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] VSPKKSTVLQ433-QQYNRVGKVE

Gln433 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Val424Ser425Pro426Lys427Lys428Ser429Thr430Val431Leu432Gln433
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln434Gln435Tyr436Asn437Arg438Val439Gly440Lys441Val442Glu443

Sequence conservation (by blast)

* References

[PubMed ID: 19148538] Anastasi G, Cutroneo G, Gaeta R, Di Mauro D, Arco A, Consolo A, Santoro G, Trimarchi F, Favaloro A, Dystrophin-glycoprotein complex and vinculin-talin-integrin system in human adult cardiac muscle. Int J Mol Med. 2009 Feb;23(2):149-59.

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