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XSB2941 : tumor protein p53 isoform b [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0053

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCellular tumor antigen p53; tumor protein p53 isoform b; p53 tumor suppressor; phosphoprotein p53; p53 antigen; p53 transformation suppressor; transformation-related protein 53
Gene NamesTP53; tumor protein p53
Gene Locus17p13.1; chromosome 17
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001119586 NM_001126114 7157 Q53GA5_HUMAN 191170 11998 N/A hsa:7157

* Information From OMIM

Description: The transcription factor p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. In addition, p53 appears to induce apoptosis through nontranscriptional cytoplasmic processes. In unstressed cells, p53 is kept inactive essentially through the actions of the ubiquitin ligase MDM2 (OMIM:164785), which inhibits p53 transcriptional activity and ubiquitinates p53 to promote its degradation. Numerous posttranslational modifications modulate p53 activity, most notably phosphorylation and acetylation. Several less abundant p53 isoforms also modulate p53 activity. Activity of p53 is ubiquitously lost in human cancer either by mutation of the p53 gene itself or by loss of cell signaling upstream or downstream of p53 (Toledo and Wahl, 2006; Bourdon, 2007; Vousden and Lane, 2007).

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* Structure Information

1. Primary Information

Length: 341 aa

Average Mass: 37.826 kDa

Monoisotopic Mass: 37.801 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
P53_TAD 1. 52946.41.1e-10
--- cleavage 25 (inside P53_TAD 5..29) ---
P53 1. 95289511.11.4e-150
P53_tetramer 1. 318339-13.69.4

3. Sequence Information

Fasta Sequence: XSB2941.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


Leu25 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19434453] Chien WP, Wong RH, Wu TC, Cheng YW, Chen CY, Lee H, Potential increase in the prognostic value of p53 mutation by Pro72 allele in stage I non-small-cell lung cancer. Ann Surg Oncol. 2009 Jul;16(7):1918-24. Epub 2009 May 12.

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