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XSB2974 : phosphoinositide-specific phospholipase C beta 1 isoform b [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0008

* Basic Information

OrganismHomo sapiens (human)
Protein Names1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1;; Phosphoinositide phospholipase C; Phospholipase C-beta-1; PLC-beta-1; PLC-I; PLC-154; phosphoinositide-specific phospholipase C beta 1 isoform b; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta 1; triphosphoinositide phosphodiesterase; phosphoinositidase C; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4; 5-bisphosphate; inositoltrisphosphohydrolase
Gene NamesPLCB1; KIAA0581; phospholipase C, beta 1 (phosphoinositide-specific)
Gene Locus20p12; chromosome 20
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_877398 NM_182734 23236 PLCB1_HUMAN 607120 15917 N/A hsa:23236

* Information From OMIM

Description: Phospholipase C-beta (PLCB) catalyzes the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate (IP2), a key step in the intracellular transduction of many extracellular signals. PLCB1 is one of several mammalian PLCB isoforms which differ in their function and expression patterns in vivo.

* Structure Information

1. Primary Information

Length: 1173 aa

Average Mass: 133.703 kDa

Monoisotopic Mass: 133.619 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Chitin_synth_1 1. 92181-119.63.6
efhand_like 1. 224315160.26e-45
PI-PLC-X 1. 318468327.62.6e-95
PI-PLC-Y 1. 539656297.82.3e-86
C2 1. 67876163.95.9e-16
Big_4 1. 835897-11.85.7
--- cleavage 880 (inside Big_4 835..897) ---
DUF1154 1. 9039466.20.0036
PLC-beta_C 1. 9971170300.92.6e-87

3. Sequence Information

Fasta Sequence: XSB2974.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


His880 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19240061] Trynka G, Zhernakova A, Romanos J, Franke L, Hunt K, Turner G, Platteel M, Ryan AW, de Kovel C, Barisani D, Bardella MT, McManus R, Van Heel DA, Wijmenga C, Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. Gut. 2009 Feb 24.

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