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XSB2978 : phospholipase C, beta 1 isoform 1 [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0008

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesPhospholipase C, beta 1; Plcb1 protein; phospholipase C; beta 1 isoform 1; phospholipase C-beta-1a; phosphoinositide phospholipase C
Gene NamesPlcb1; RP23-418D21.3-001; phospholipase C, beta 1
Gene Locus2 76.7 cM; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001139302 NM_001145830 18795 Q6PDH1_MOUSE N/A N/A N/A mmu:18795

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1216 aa

Average Mass: 138.396 kDa

Monoisotopic Mass: 138.309 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Chitin_synth_1 1. 92181-112.30.67
efhand_like 1. 224315164.04.4e-46
PI-PLC-X 1. 318468327.62.6e-95
PI-PLC-Y 1. 539656297.62.6e-86
C2 1. 67876159.01.7e-14
--- cleavage 880 ---
DUF1154 1. 9039466.10.0037
PLC-beta_C 1. 9971189429.26.6e-126

3. Sequence Information

Fasta Sequence: XSB2978.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] APKPPSQAPH880-SQPAPGSVKA

His880 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala871Pro872Lys873Pro874Pro875Ser876Gln877Ala878Pro879His880
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser881Gln882Pro883Ala884Pro885Gly886Ser887Val888Lys889Ala890

Sequence conservation (by blast)

* References

[PubMed ID: 19385066] O'Carroll SJ, Mitchell MD, Faenza I, Cocco L, Gilmour RS, Nuclear PLCbeta1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex. Cell Signal. 2009 Jun;21(6):926-35.

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