logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2984 : troponin T2, cardiac isoform b [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0066

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesTroponin T, cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT; troponin T2; cardiac isoform b; cardiac TnT
Gene NamesTnnt2; troponin T2, cardiac
Gene Locus1 60.0 cM; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001123648 NM_001130176 21956 TNNT2_MOUSE N/A N/A N/A mmu:21956

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 301 aa

Average Mass: 35.825 kDa

Monoisotopic Mass: 35.804 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 81 ---
Troponin 1. 106250178.91.5e-50

3. Sequence Information

Fasta Sequence: XSB2984.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] VEDTKPKPSR81-LFMPNLVPPK

Arg81 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Val72Glu73Asp74Thr75Lys76Pro77Lys78Pro79Ser80Arg81
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu82Phe83Met84Pro85Asn86Leu87Val88Pro89Pro90Lys91

Sequence conservation (by blast)

* References

[PubMed ID: 19166829] Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y, Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol. 2009 Mar 15;327(2):376-85. Epub 2009 Jan 3.

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