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XSB3000 : Chain A, Crystal Structure Of The Rhoa.Gdp-Rhogdi Complex

[ CaMP Format ]

This entry is computationally expanded from SB0038

* Basic Information

OrganismHomo sapiens (human)
Protein NamesTransforming protein RhoA; H12
Gene NamesARH12, ARHA, RHO12; ARH12; ARHA; RHO12
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1CC0_A N/A N/A RHOA_HUMAN N/A N/A N/A hsa:387

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 190 aa

Average Mass: 21.410 kDa

Monoisotopic Mass: 21.396 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Ras 1. 7180326.94.1e-95
--- cleavage 180 (inside Ras 7..180) ---

3. Sequence Information

Fasta Sequence: XSB3000.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1A2B (X-ray; 240 A; A=1-181), 1CC0 (X-ray; 500 A; A/C=1-190), 1CXZ (X-ray; 220 A; A=1-181), 1DPF (X-ray; 200 A; A=1-180), 1FTN (X-ray; 210 A; A=1-193), 1KMQ (X-ray; 155 A; A=4-181), 1LB1 (X-ray; 281 A; B/D/F/H=1-189), 1OW3 (X-ray; 180 A; B=1-193), 1S1C (X-ray; 260 A; A/B=1-181), 1TX4 (X-ray; 165 A; B=3-179), 1X86 (X-ray; 322 A; B/D/F/H=1-193), 1XCG (X-ray; 250 A; B/F=3-180), 2RGN (X-ray; 350 A; C/F=1-193)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)


Gln180 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 9195882] Keep NH, Barnes M, Barsukov I, Badii R, Lian LY, Segal AW, Moody PC, Roberts GC, A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure. 1997 May 15;5(5):623-33.

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